Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Lhx2  LIM homeobox protein 2   (Synonyms: ap, apterous, Lh-2, LH2A)
Results	Reference
1	J:152710 Aldinger KA, Lehmann OJ, Hudgins L, Chizhikov VV, Bassuk AG, Ades LC, Krantz ID, Dobyns WB, Millen KJ, FOXC1 is required for normal cerebellar development and is a major contributor to chromosome 6p25.3 Dandy-Walker malformation. Nat Genet. 2009 Sep;41(9):1037-42
1	J:69624 Bermingham NA, Hassan BA, Wang VY, Fernandez M, Banfi S, Bellen HJ, Fritzsch B, Zoghbi HY, Proprioceptor pathway development is dependent on math1. Neuron. 2001 May;30(2):411-22
1	J:170488 Blank MC, Grinberg I, Aryee E, Laliberte C, Chizhikov VV, Henkelman RM, Millen KJ, Multiple developmental programs are altered by loss of Zic1 and Zic4 to cause Dandy-Walker malformation cerebellar pathogenesis. Development. 2011 Mar;138(6):1207-16
1	J:185651 Bluske KK, Vue TY, Kawakami Y, Taketo MM, Yoshikawa K, Johnson JE, Nakagawa Y, beta-Catenin signaling specifies progenitor cell identity in parallel with Shh signaling in the developing mammalian thalamus. Development. 2012 Aug;139(15):2692-702
1	J:102513 Cheng L, Samad OA, Xu Y, Mizuguchi R, Luo P, Shirasawa S, Goulding M, Ma Q, Lbx1 and Tlx3 are opposing switches in determining GABAergic versus glutamatergic transmitter phenotypes. Nat Neurosci. 2005 Nov;8(11):1510-5
1	J:110657 Cheng X, Hsu CM, Currle DS, Hu JS, Barkovich AJ, Monuki ES, Central roles of the roof plate in telencephalic development and holoprosencephaly. J Neurosci. 2006 Jul 19;26(29):7640-9
1	J:119033 Chizhikov VV, Lindgren AG, Currle DS, Rose MF, Monuki ES, Millen KJ, The roof plate regulates cerebellar cell-type specification and proliferation. Development. 2006 Aug;133(15):2793-804
1*	J:332642 Cohen-Gulkar M, David A, Messika-Gold N, Eshel M, Ovadia S, Zuk-Bar N, Idelson M, Cohen-Tayar Y, Reubinoff B, Ziv T, Shamay M, Elkon R, Ashery-Padan R, The LHX2-OTX2 transcriptional regulatory module controls retinal pigmented epithelium differentiation and underlies genetic risk for age-related macular degeneration. PLoS Biol. 2023 Jan;21(1):e3001924
1	J:160034 Davis SW, Castinetti F, Carvalho LR, Ellsworth BS, Potok MA, Lyons RH, Brinkmeier ML, Raetzman LT, Carninci P, Mortensen AH, Hayashizaki Y, Arnhold IJ, Mendonca BB, Brue T, Camper SA, Molecular mechanisms of pituitary organogenesis: In search of novel regulatory genes. Mol Cell Endocrinol. 2010 Jul 8;323(1):4-19
1	J:316684 Ding Q, Balasubramanian R, Zheng D, Liang G, Gan L, Barhl2 Determines the Early Patterning of the Diencephalon by Regulating Shh. Mol Neurobiol. 2017 Aug;54(6):4414-4420
1	J:181907 Ding Q, Joshi PS, Xie ZH, Xiang M, Gan L, BARHL2 transcription factor regulates the ipsilateral/contralateral subtype divergence in postmitotic dI1 neurons of the developing spinal cord. Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1566-71
1	J:178994 Fantauzzo KA, Christiano AM, Trps1 activates a network of secreted Wnt inhibitors and transcription factors crucial to vibrissa follicle morphogenesis. Development. 2012 Jan;139(1):203-14
1	J:290813 Fiore L, Takata N, Acosta S, Ma W, Pandit T, Oxendine M, Oliver G, Optic vesicle morphogenesis requires primary cilia. Dev Biol. 2020 Jun 15;462(2):119-128
1	J:112208 Fotaki V, Yu T, Zaki PA, Mason JO, Price DJ, Abnormal positioning of diencephalic cell types in neocortical tissue in the dorsal telencephalon of mice lacking functional Gli3. J Neurosci. 2006 Sep 6;26(36):9282-92
1	J:199799 Gordon PJ, Yun S, Clark AM, Monuki ES, Murtaugh LC, Levine EM, Lhx2 balances progenitor maintenance with neurogenic output and promotes competence state progression in the developing retina. J Neurosci. 2013 Jul 24;33(30):12197-207
1	J:305179 Gray de Cristoforis A, Ferrari F, Clotman F, Vogel T, Differentiation and localization of interneurons in the developing spinal cord depends on DOT1L expression. Mol Brain. 2020 May 29;13(1):85
1*	J:331142 Han P, She Y, Yang Z, Zhuang M, Wang Q, Luo X, Yin C, Zhu J, Jaffrey SR, Ji SJ, Cbln1 regulates axon growth and guidance in multiple neural regions. PLoS Biol. 2022 Nov;20(11):e3001853
1	J:50972 Lee KJ, Mendelsohn M, Jessell TM, Neuronal patterning by BMPs: a requirement for GDF7 in the generation of a discrete class of commissural interneurons in the mouse spinal cord. Genes Dev. 1998 Nov 1;12(21):3394-407
1	J:310819 Makrides N, Panayiotou E, Fanis P, Karaiskos C, Lapathitis G, Malas S, Sequential Role of SOXB2 Factors in GABAergic Neuron Specification of the Dorsal Midbrain. Front Mol Neurosci. 2018;11:152
1	J:156171 Manuel M, Martynoga B, Yu T, West JD, Mason JO, Price DJ, The transcription factor Foxg1 regulates the competence of telencephalic cells to adopt subpallial fates in mice. Development. 2010 Feb;137(3):487-97
1	J:183861 Marcos-Mondejar P, Peregrin S, Li JY, Carlsson L, Tole S, Lopez-Bendito G, The lhx2 transcription factor controls thalamocortical axonal guidance by specific regulation of robo1 and robo2 receptors. J Neurosci. 2012 Mar 28;32(13):4372-85
1	J:92188 Millen KJ, Millonig JH, Hatten ME, Roof plate and dorsal spinal cord dl1 interneuron development in the dreher mutant mouse. Dev Biol. 2004 Jun 15;270(2):382-92
1	J:73082 Monuki ES, Porter FD, Walsh CA, Patterning of the dorsal telencephalon and cerebral cortex by a roof plate-lhx2 pathway. Neuron. 2001 Nov 20;32(4):591-604
1	J:116182 Morales D, Hatten ME, Molecular markers of neuronal progenitors in the embryonic cerebellar anlage. J Neurosci. 2006 Nov 22;26(47):12226-36
1	J:324116 Morita R, Sanzen N, Sasaki H, Hayashi T, Umeda M, Yoshimura M, Yamamoto T, Shibata T, Abe T, Kiyonari H, Furuta Y, Nikaido I, Fujiwara H, Tracing the origin of hair follicle stem cells. Nature. 2021 Jun;594(7864):547-552
1	J:330186 Nguyen H, Sokpor G, Parichha A, Pham L, Saikhedkar N, Xie Y, Ulmke PA, Rosenbusch J, Pirouz M, Behr R, Stoykova A, Brand-Saberi B, Nguyen HP, Staiger JF, Tole S, Tuoc T, BAF (mSWI/SNF) complex regulates mediolateral cortical patterning in the developing forebrain. Front Cell Dev Biol. 2022;10:1011109
1	J:179784 Sanuki R, Onishi A, Koike C, Muramatsu R, Watanabe S, Muranishi Y, Irie S, Uneo S, Koyasu T, Matsui R, Cherasse Y, Urade Y, Watanabe D, Kondo M, Yamashita T, Furukawa T, miR-124a is required for hippocampal axogenesis and retinal cone survival through Lhx2 suppression. Nat Neurosci. 2011 Sep;14(9):1125-34
1	J:222256 Sigulinsky CL, German ML, Leung AM, Clark AM, Yun S, Levine EM, Genetic chimeras reveal the autonomy requirements for Vsx2 in embryonic retinal progenitor cells. Neural Dev. 2015;10:12
1	J:184006 Tang K, Rubenstein JL, Tsai SY, Tsai MJ, COUP-TFII controls amygdala patterning by regulating neuropilin expression. Development. 2012 May;139(9):1630-9
1	J:237527 Thein T, de Melo J, Zibetti C, Clark BS, Juarez F, Blackshaw S, Control of lens development by Lhx2-regulated neuroretinal FGFs. Development. 2016 Nov 01;143(21):3994-4002
1	J:282827 Tulloch AJ, Teo S, Carvajal BV, Tessier-Lavigne M, Jaworski A, Diverse spinal commissural neuron populations revealed by fate mapping and molecular profiling using a novel Robo3(Cre) mouse. J Comp Neurol. 2019 Dec 15;527(18):2948-2972